Cyclosporin A

Research use only, not for human use.

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.(In Vitro):Cyclosporin A is able to bind with the cyclophilin in T cells. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM. Cyclosporin A suppresses the nuclear translocation of NF-AT. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM.(In Vivo):Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs. Cyclosporin A can be used in organ transplantation to prevent rejection.

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NSC 290193

Metabolic Enzyme/Protease

Phosphatase

calcineurin phosphatase

Inflammation/Immunology

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59865-13-3

1202.64

C62H111N11O12

>98% (HPLC)

Ethanol: 100 mg/mL warmed (83.15 mM); DMSO: 100 mg/mL warmed (83.15 mM)

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

(-20℃)

With Ice Pack

≥ 2 years