Cyclosporin A ( NSC 290193 )

Catalog No. M15224 CAS No. 59865-13-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Cyclosporin A
Note

Research use only, not for human use.
Brief Description

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.
Description

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.
Synonyms

NSC 290193
Pathway

Metabolic Enzyme/Protease
Target

Phosphatase
Recptor

calcineurin phosphatase
Research Area

Inflammation/Immunology
Indication

——

CAS Number

59865-13-3
Formula Weight

1202.64
Molecular Formula

C62H111N11O12
Purity

>98%(HPLC)
Solubility

Ethanol: 100 mg/mL warmed (83.15 mM); DMSO: 100 mg/mL warmed (83.15 mM)
SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Chemical Name

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

1.Handschumacher RE, et al. Science, 1984, 226(4674), 544-547.

Calculator

molnova catalog